Typical pooled platelet psoralen-treated (PPPT) unit
PPPT unit with aggregates
Typical apheresis platelet psoralen-treated (APPT) unit
APPT unit with aggregates
Photo not available.
Particulate matter can be the result of blood collection and/or component manufacturing processes. There are several categories of particulate matter that may be found within platelet units:
Clots and fibrin strands
Clots may appear as white and opaque masses that do not dissipate with gentle manipulation.
Clots and fibrin strands result from the activation of the clotting processes and can be a mixture of clotting proteins (including fibrin) and platelets. Blood is collected and processed in bags that contain anticoagulants to inhibit the clotting processes. Blood components containing clots and / or fibrin strands should NOT be transfused and should be reported to Canadian Blood Services.
Aggregates may appear as small white and opaque masses that generally dissipate with gentle manipulation and/or agitation.
Aggregates have been reported in some pathogen-reduced platelet components. Platelets containing visible particles are not inferior to particle-free concentrates.
Placing units in landscape orientation on an agitator may help reduce aggregate formation.