LearnTransfusion Seminar

Scientific session: What pre-clinical studies teach us about preventing hemolytic disease of the fetus and newborn?


Event details

Presented by

Dr. Yoelys Cruz-Leal
Postdoctoral Fellow
Canadian Blood Services, Toronto

Learning objectives

  1. Describe the cause of hemolytic disease of the fetus and newborn (HDFN) and evaluate the effectiveness of current prophylaxis.
  2. Analyze the proposed mechanisms of action of Rh immune globulin (RhIg) in preventing HDFN.
  3. Evaluate the findings of preclinical studies on preventing HDFN, and synthesize the available evidence to develop a comprehensive understanding of the current state of research in this area.


  1. Cruz-Leal Y, Lazarus AH. Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression? Transfusion. 2021: 61(4):1004-1006. doi: 10.1111/trf.16309.
  2. Winter D.P., KaminskiA, Tjoa M and Oepkes D. Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape. BMC Pregnancy and Childbirth (2023) 23:12 https://doi.org/10.1186/s12884-022-05329-z
  3. Wabnitz H, Cruz-Leal Y, Lazarus AH. Antigen copy number and antibody dose can determine the outcome of erythrocyte alloimmunization inducing either antibody-mediated immune suppression or enhancement in a murine model. Transfusion. 2023. doi: 10.1111/trf.17284.


Note: The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada.





To be added to the distribution list for the LearnTransfusion series, send an email to learn.transfusion@blood.ca  with “Weekly Transfusion Medicine Seminars” in the subject line. Include your name and complete e-mail address in the body of the e-mail and confirm that you would like to be added to the distribution list for the LearnTransfusion series. You will then receive weekly email notifications of upcoming series events with details on how to join the webinars (e.g.,  link to register for the webinar).

The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services, is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.