Scientific Session: Blood Donor Factors and the Immunomodulatory Activity of Stored Red Cell Concentrates

Presented by:

Dr. Jason Acker MBA PhD
Senior Research Scientist, Centre for Innovation
Canadian Blood Services

Objectives:

1.    Challenge you to think about what other factors besides storage may be affecting “What’s in the Bag”.
2.    Understand biological mechanisms affecting sex dimorphism in transfusion medicine.
3.    Share evidence for why donor sex may have an immunological effect on blood recipients.

References:

1.    Roubinian N.H. et al. Effect of donor, component and recipient characteristics on hemoglobin increments following red blood cell transfusions. Blood 2019; 134: 1003-1013.
2.    Noulsri E. and Palasuwan, A. Effects of donor age, donor sex, blood-component processing, and storage on cell-derived microparticle concentrations in routine blood-component preparation. Transfusion and Apheresis Sciences 2018; 57: 587-592.
3.    Almizraq, R.J. et al. Platelet vesicles are potent inflammatory mediators in red blood cell products and washing reduces the inflammatory phenotype. Transfusion2020; 60): 378-390.
4.    Alshalani, A. et al. Biological mechanisms implicated in adverse outcomes of sex mismatched transfusions. Transfusion and Apheresis Sciences. 2019; 58: 351-356.
5.    Heddle, N.M. et al. The association between donor sex and age and mortality in blood transfusion recipients: An exploratory analysis. Transfusion 2019; 59: 482-491.
6.    Kipkeu, B. et al. Red cell supernatant effects on endothelial cell function is influenced by donor age and sex. ISBT Science Series 2018; 13: 446-459.
7.    Ning, S. et al. Exploring donor, product and recipient factors and their impact on red cell post-transfusion outcomes. Transfusion Medicine Review 2018; 32): 28-35.
8.    Chassé, M., et al. Association of blood donor age and sex with survival after red blood cells transfusion. JAMA Internal Medicine 2016; 176:1307-1314.

Note: The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada.

To register for the LearnTransfusion series, send an email to learn.transfusion@blood.ca with  “Weekly Transfusion Medicine Seminars” in the subject line. Include your name and complete e-mail address in the body of the e-mail, and confirm that you would like to register for the LearnTransfusion series. You will then receive weekly email notifications of upcoming series events with details on how to join the webinars (e.g., call-in number and a link to register for the webinar).

The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.