Alloimmunization is common in patients with sickle cell disease and may complicate transfusion therapy.
Patient phenotyping and prophylactic matching to reduce alloimmunization is recommended.
Transfusion requirements and the presence or absence of red cell antibodies influence recommendations on the extent of phenotyping for patients with sickle cell disease.
Limited evidence exists on the impact of the storage age of blood in this population, but provision of fresh units imposes significant challenges and may compromise availability of optimally phenotype-matched units.
To accompany the 2020 Canadian clinical practice guideline for the medical management of deceased organ donors, Canadian Blood Services has created a knowledge translation tool specific to families and substitute decision makers.
Evidence bulletins are an attractive, user-friendly, evidence-based knowledge translation tool. Each bulletin is a one-page, letter-size card addressing one specific intervention in the management of deceased donors, highlighting:
These order sets for deceased organ donor management are based on the Canadian clinical practice guideline published in 2020. Hospitals, intensive care units, and provincial organ donation organizations may adopt or adapt these as standing orders to optimize organ function during medical management of neurologically deceased organ donors.
April 1, 2020 - In the evolving COVID-19 pandemic, administrative and medical leads of the organ donation and transplantation community across Canada are meeting regularly to collaboratively develop recommendations that can be used by provincial organ donation organizations and regional transplant and donation programs to guide the administration of organ and tissue donation and transplantation services.
Canadian Blood Services works with the Organ and Tissue Donation and Transplantation (OTDT) community to improve national system performance. We do this through the development of leading practices, professional education, public awareness and data analysis and reporting. We also manage clinical programs that support interprovincial sharing of organs.
National OTDT Data Working Groups have been created to establish standardized data sets that will allow alignment of information collected and reported across the country. These reports represent the first step in building a comprehensive national data set for organ and tissue donation and transplantation.