Topic: Some Powerful Poison - Improving Outcomes in Immune Thrombotic Thrombocytopenic Purpura (iTTP)

Presented by

Dr. Katerina Pavenski

St. Michaels Hospital, UHN, University of Toronto

Learning objectives

Following this presentation, the learner should be able to

• To describe epidemiology, pathophysiology, and complications of iTTP
• To list evidence-based therapeutic options in iTTP

Additional Resources:

2025 focused update of the 2020 ISTH guidelines for management of thrombotic thrombocytopenic purpura.

Zheng XL, Al-Housni Z, Cataland SR, Coppo P, Geldziler B, Germini F, Iorio A, Keepanasseril A, Masias C, Matsumoto M, McCrae KR, McIntyre J, Mustafa RA, Peyvandi F, Russell L, Tarawneh R, Vesely SK; International Society on Thrombosis and Haemostasis.J Thromb Haemost. 2025 Nov;23(11):3711-3732. doi: 10.1016/j.jtha.2025.06.002. Epub 2025 Jun 17.PMID: 40533296 Free PMC article.

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura.

Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F.J Thromb Haemost. 2020 Oct;18(10):2496-2502. doi: 10.1111/jth.15010. Epub 2020 Sep 11.PMID: 32914526 Free PMC article.

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura.

Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F.J Thromb Haemost. 2020 Oct;18(10):2486-2495. doi: 10.1111/jth.15006. Epub 2020 Sep 11.PMID: 32914582 Free PMC article.

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The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services, is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.