Topic Teaching: Weiner Stew!: Current Knowledge Review of RHD & RHCE Variants

Presented by:

Christine M. Cserti-Gazdewich, HBSc MD FRCPC
Assistant Professor, University of Toronto,
Department of Medicine,
Laboratory Medicine/Pathobiology
& Division of Hematology

Objectives:

1.   Compare and contrast terms in diagnostic immunogenetics (partial, weak, variant, hybrid, SNP, genotyping, sequencing).
2.   Identify criteria for molecular testing for RH variation.
3.   Describe transfusion management for RH variation.

References:

1.   Chou ST, Alsawas M, Fasano RM, et al.: American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv 2020; 4: 327-55.
2.   Flegel WA, Denomme GA, Queenan JT, et al.: It's time to phase out "serologic weak D phenotype" and resolve D types with RHD genotyping including weak D type 4.   Transfusion 2020; 60: 855-9.
3.   Westhoff CM: Blood group genotyping. Blood 2019; 133: 1814-20.
4.   Chou ST, Evans P, Vege S, et al.: RH genotype matching for transfusion support in sickle cell disease. Blood 2018; 132: 1198-207.
5.   Chou ST, Flanagan JM, Vege S, et al.: Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia. Blood Adv 2017; 1: 1414-22.
6.   Chou ST, Westhoff CM: The role of molecular immunohematology in sickle cell disease. Transfus Apher Sci 2011; 44: 73-9.
7.   Flegel WA: The genetics of the Rhesus blood group system. Blood Transfus 2007; 5: 50-7.

Note: The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada.

To register for the LearnTransfusion series, send an email to learn.transfusion@blood.ca with  “Weekly Transfusion Medicine Seminars” in the subject line. Include your name and complete e-mail address in the body of the e-mail, and confirm that you would like to register for the LearnTransfusion series. You will then receive weekly email notifications of upcoming series events with details on how to join the webinars (e.g., call-in number and a link to register for the webinar).

The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.