LearnTransfusion Seminar

Journal Club: Intravenous immunoglobulin related hemolysis, review of the product associated risk factors


Event details

Presented by

Dr. Ahmad Alharbi
Transfusion Medicine Physician Trainee
McMaster University, Hamilton

Learning objectives

  1. Review the pathogenesis and definition of IVIG related hemolysis.
  2. Identify the incidence and risk factors for IVIG related hemolysis.
  3. Recognize the IVIG products with low isoagglutinin titers.
  4. Criticize the product associated risk factors reported in the literatures.


  1. Pendergrast J et al. A prospective observational study of the incidence, natural history, and risk factors for intravenous immunoglobulin‐mediated hemolysis. Transfusion. 2021;61(4):1053–63.
  2. Wallenhorst C  et al. Anti-A/B isoagglutinin reduction in an intravenous immunoglobulin product and risk of hemolytic anemia: a hospital‐based cohort study. Transfusion. 2020;60(7):1381–90.
  3. Hoefferer L et al. Isoagglutinin reduction by a dedicated immunoaffinity chromatography step in the manufacturing process of human immunoglobulin products. Transfusion. 2015;55(S2):S117–21.
  4. Bellac CL et al. The role of isoagglutinins in intravenous immunoglobulin-related hemolysis. Transfusion (Paris). 2015;55(S2):S13–22.
  5. Shebl A et al. Isoagglutinin reduction in intravenous immunoglobulin by specific immunoaffinity chromatography reduces its reporting rates of hemolytic reactions: an analysis of spontaneous adverse event reports. Transfusion 2020;60(6):1278–86.
  6. Cuesta H et al. Incidence and risk factors for intravenous immunoglobulin-related hemolysis: A systematic review of clinical trial and real-world populations. Transfusion 2022;62:1894–907


Note: The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada.





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The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services, is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.