Immunohematology Boot Camp: Duffy System (25EL-509)

This program explores the Duffy (FY) blood group system antigens and related antibodies using a lecture format with accompanying complex serologic case studies. Beginning with an overview of the structure and physiologic role of the FY glycoprotein, ACKR1 (Atypical Chemokine Receptor 1), this program will describe the significance of this glycoprotein as a ligand for malarial parasites and the effect on natural selection for the Fy(a-b-) phenotype. The molecular basis of FY blood system antigens along with genetic variations that affect FY blood group system antigen expression will be described. Furthermore, the link between Fy(a-b-) red blood cell phenotype and Duffy-null Associated Neutrophil Count (DANC) will be examined highlighting the critical role of the transfusion service laboratory in confirming the diagnosis to ensure appropriate clinical management. Finally, this program will review the clinical significance of antibodies directed against FY blood group system antigens and utilize case studies to illustrate approaches to identify these antibodies in the transfusion service laboratory.

Presented by

Elizabeth P. Crowe, MD, PhD
Director/Moderator
Assistant Professor, Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine; Medical Director, Blood Bank, Johns Hopkins Hospital
Baltimore, MD

Kathy Haddaway, MLS(ASCP)CMSBBCM
Speaker
Technical Specialist II - Transfusion Medicine Division, Johns Hopkins Hospital Baltimore, MD

Learning objectives

After participating in this educational activity, participants should be able to:

• Describe the function of the FY Glycoprotein, ACKR1 and its role in malarial infections.
• Explain the molecular basis of the Fy(a-b-) phenotype.
• Define Duffy-null Associated Neutrophil Count (DANC) and its implications in clinical practice.
• Discuss the clinical significance of antibody formation to the Duffy antigens.
• Interpret complex serologic case studies using characteristics of antibodies in the Duffy system.

Registration

Registration includes access to both the live and on-demand version of this eCast. Registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time, you will receive access to the on-demand eCast when it is available.

For additional information and to register as a single viewer or group, visit the AABB event webpage. Please note: Registration fees are required for AABB events.