Seminar Series: Protective and pathogenic paradigms of germinal centers

The diversity of the antibody-producing B cell repertoire plays a critical role in the defense against pathogens, but poor regulation of the processes that generate that diversity can also lead to autoimmunity. High-affinity antibody responses are generated, in part, by maturation of antibody-producing B cells in germinal centers (GCs). These GCs improve antibody affinity through iterative rounds of proliferation, mutation, and selection. However, defects in GC maintenance and selection can cause autoimmunity. The Domeier laboratory is focused on understanding how modulation of the GC can impact long-lived B cell responses to provide protection (vaccine design) or activate autoreactive B cell responses (autoimmunity).

This lecture is part of the CBR lecture series. Held on Wednesdays from 1-2pm PT, CBR seminars feature insightful scientific talks, with speakers from a range of clinical, industry and academic backgrounds.

Presented by

Phillip Domeier, PhD
Assistant Professor, Microbiology and Immunology, UBC
Member, Prepare for Pandemics through Advanced Research in Evolution (PrePARE) Cluster, UBC

Hosted by Dr. Jay Kizhakkedathu

Registration

For information about CBR Seminar series events, visit the CBR website: CBR Seminars | Centre for Blood Research (ubc.ca). To receive Zoom access details for CBR Seminar series events, contact Kaitlyn Chuong (kaitlyn.chuong@ubc.ca).