Journal Club: Beyond Plasma Exchange: Caplacizumab Treatment for Acquired Thrombotic Trombocytopenic Purpura

Speaker:

Melissa Boileau, MD
Transfusion Medicine Physician Trainee
University of Toronto

Objectives:

1.  Describe the clinical approach to the diagnosis of TTP.
2.  Discuss current treatment of TTP.
3.  Critically appraise an article on the clinical impact of Caplacizumab for patients with TTP.

References:

1.  Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.  Scully M, Cataland SR, Peyvandi F, Coppo P, Knobl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators.  N Engl J Med. 2019 Jan 24;335-346, doi: 10.1056/NEJMoa1806311.  Epub 2019 Jan 9. PMID 30625070.

Note:  The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal Colleage of Physicians and Surgeons of Canada.

To register for the LearnTransfusion series, send an email to learn.transfusion@blood.ca with  “Weekly Transfusion Medicine Seminars” in the subject line. Include your name and complete e-mail address in the body of the e-mail, and confirm that you would like to register for the LearnTransfusion series. You will then receive weekly email notifications of upcoming series events with details on how to join the webinars (e.g., call-in number and a link to register for the webinar).

The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.